Thursday, May 15, 2014

Getting Started with Genome Mate using GedMatch Data

Genome Mate is a desktop tool used to organize in one place the data collected while researching DNA comparisons.  Besides data storage it has many features to aid in identifying common ancestors.  It can be downloaded at http://genomemate.org/



The following guide was originally put together by George Cunningham and published with his permission.  It has been edited to reflect changes in the application.


GedMatch Getting Started Guide

The very first step is to either create a profile in Genome Mate or make sure the current profiles contain the GedMatch kit # exactly as it appears on GedMatch.

Step 1:  Create a Profile


  • First create a profile in Genome Mate for each kit that you manage
    • Profiles > Add new profile
  • Put in a name, any name will do, but
    • You are a good choice for the profile person.  
    • If your going to use data from 23andMe for the profile person, the profile name MUST match the 23andMe name.
  • Put the GedMatch kit # for the profile person.  If this is not entered, no DNA segment data will be displayed on the main page for this person.
  • Load a gedcom file for each profile if you have one.  If not just continue.
    • The gedcom file can be all of your relatives and more
    • Genome Mate will ask you for the name to associate with the profile person, and will strip out all but the profile person's direct ancestors.
    • The gedcom file format must be 5.5 (not 5.5.1) in UTF8 format

Step 2:  GedMatch Names and Email Addresses

GedMatch Import Options

This function will load the first 1500 GedMatch kits with their name and email addresses into Genome Mate Relative records.  To view the data, on the Main page click on Relatives.
  • On GedMatch:   'One-to-many' matches > Enter Kit # > Display Results > Highlight data (Ctrl or Cmd a) > Copy data (Ctrl or Cmd c)
  • In Genome Mate > Import Data > Select Data Source GedMatch > (2) Load/Update GedMatch Relative Records > Paste data (Ctrl or Cmd v) > Format > Close


Step 3:  Load GedMatch Chromosome Browser Data

These functions will load GedMatch DNA segments.  The GedMatch kit # must be one that is assigned to one of the Genome Mate profile people (see Profiles) or the matches will be considered ICW data. This data will be displayed on the main page.
Bulk Load option: 
  • On GedMatch:  'One-to-many' matches > Enter Kit # > Display Results > In the column 4, check up to 200 kits for comparison >  Chr-Browse > "Here" > Highlight data (Ctrl or Cmd a) > Copy data (Ctrl or Cmd c) 
  • In Genome Mate > Import Data > Select Data Source GedMatch > (1) Load GedMatch Chromosome Browser Data > Paste data (Ctrl or Cmd v) > Format > Add > Close

Individual match option: 
  • On GedMatch:  'One-to-one' compare > Enter profile kit #> Enter 2nd Kit# > Submit> Paste data (Ctrl or Cmd v) > Format > Add > Close 
  • In Genome Mate >  Import Data > Select Data Source GedMatch > (3) Copy/Paste GedMatch 1 to 1 Comparison Matches > Format > Add > Close 


Step 4:  Load Individual ICW Data

In common with (ICW) data can be loaded for individuals of interest from the GedMatch 1 to Many function for the first 1500 matches.  The ICW icon for the individual loaded will be a gold color to help with tracking.
  • On GedMatch:   'One-to-many' matches > Enter Kit # > Display Results > Highlight data (Ctrl or Cmd a) > Copy data (Ctrl or Cmd c) 
  • In Genome Mate > Click on a DNA Segment on the Main Page > Add ICW > Paste data (Ctrl or Cmd v) > Format


Hints and Tips

  • There are two small arrows going in a circle to the left of your profile name. 
  • Left click to show overlapping segments.  Escape to return to the original screen.
  • Right click to bring up an overlapping segment dialog
  • Choose a Relative Name in the list of matches. 
  1. Choose a relative who matches you on more than one chromosome.
  2. Right click on it to show all matches
  3. Escape to return to the original screen.


  • Some Relatives will have a small symbol (Mark ICW segments) to the left of their name.   Hover (do not click) your mouse over the symbol. 

  • A series of colored bars will show you the relatives who are in common with the one you are hovering over.  
  • These people are related but not necessarily on the currently selected segment. 
  • Some ICW group symbols are in orange. 
  • The orange color means that the segment crosses a centromere or other false positive region, so the meaningful length is much shorter than the displayed length.   
  • If you hover over the symbol, it will show the length of the centromere or false positive range. 

Backups & Restores 

The words of wisdom on creating backup files cannot be overemphasized.   Experimentation is encouraged, but make sure you have a safe harbor.


Donations

Genome Mate's continued development, support and enhancements on the internet are funded by your donations.  If you use the application, please consider making a donation through Paypal.

Copyright © Beckins LLC 2013-2014

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